Respiratory Exposure Tests in Aspirin Exacerbated Respiratory Disease

Abstract Purpose of review Controlled oral provocation test with aspirin is considered the “gold standard” for diagnosing hypersensitivity to NSAIDs (non-steroid anti-inflammatory drugs). Newer techniques respiratory exposure tests, bronchial and nasal respectively, have been nonetheless developed, as they are safer, less likely cause a systemic reaction, time-consuming than (acetyl-salicylic acid). These tests also particularly useful when challenge testing contraindicated. The aim this paper update detailed protocols challenges lysine-aspirin, salt acetyl-salicylic acid, more soluble irritative. Recent findings Current guidelines recommend standardized nasal, especially in patients suspected N-ERD (NSAID-exacerbated disease). Summary Nasal safe, not that sensible diagnosis N-ERD. So, cases high suspicion negative an should be performed before ruling out diagnosis. by trained personnel specialized allergy clinics. Further consensus on protocol interpretation still needed.